HCID 22341901、化合物 → Acetyl-5-aminosalicylic acid

HRID 1787882

反応式

HRID 1787882 の反応式
[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([NH:14]C(OC(C)(C)C)=O)=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2]>C(O)(C(F)(F)F)=O.C(Cl)Cl>[C:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2]

参加物

3

反応物 1

HCID 22341901HCID 22341901、化合物

生成物 1

HCID 13140652Acetyl-5-aminosalicylic acid収率 97.4%

試薬・触媒・溶媒 1

HCID 21863450Trifluoroacetic acid methylene chloride溶媒

実験手順

The mixture of 2-ethanoyloxy-5-tert-butoxycarbonylaminobenzoic acid (1.01 g, 3.42 mmole) in TFA/CH2Cl2 (20.0 ml. 1:1 v/v) was stirred for 30 min at room temperature. After the reaction mixture was concentrated, the residue was dissolved in ether. The resulting residue was recrystallized from ethyl acetate/hexane to give 0.65 g (97% yield) of 2-ethanoyloxy-5-aminobenzoic acid as a white solid.

後処理

  1. concentrationAfter the reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in ether
  3. customThe resulting residue was recrystallized from ethyl acetate/hexane

出典と根拠

ORDレコード
ord-f99c4245f5024eafbed92d5ba276e740
出典データセット
uspto-grants-2009_03
特許番号
US07511074B2

関連ノート

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