Triethylamine → 1,3-Benzodioxole, 5-(chloromethyl)-
反応式
[CH2:1](O)[C:2]1[CH:10]=[CH:9][C:8]2[O:7][CH2:6][O:5][C:4]=2[CH:3]=1.C(N(CC)CC)C.S(Cl)([Cl:21])=O>C1C=CC=CC=1>[Cl:21][CH2:1][C:2]1[CH:10]=[CH:9][C:8]2[O:7][CH2:6][O:5][C:4]=2[CH:3]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
Piperonyl alcohol (10 g, 65.7 mmol) was dissolved in benzene. Triethylamine (11 ml, 78.8 mmol) and thionyl chloride (11 ml, 131.4 mmol) were added dropwise thereto and was stirred for 24 hours at 0° C. The reaction mixture was extracted with sodium bicarbonate and ethyl acetate, the organic layer was separated, and dried over anhydrous magnesium sulfate to obtain 5-chloromethyl benzo[1,3]dioxol (11.2 g, yield 100%).
後処理
- extractionThe reaction mixture was extracted with sodium bicarbonate and ethyl acetate
- customthe organic layer was separated
- dry with materialdried over anhydrous magnesium sulfate
出典と根拠
- ORDレコード
- ord-d083df6e630e4365a26adb042fc2f702
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741323B2
反応ノート
読み込み中…