Methane → HCID 178518411、化合物

反応式

C1(N[C:8]2[C:9]3[S:28][CH2:27][CH2:26][C:10]=3N=C(N3CCN(C4C=CC=CC=4)CC3)N=2)CCCCC1.[NH2:29][C:30]([NH2:32])=[O:31].C.[OH-:34].[Na+]>>[N:29]1[C:10]2[CH:26]=[CH:27][S:28][C:9]=2[C:8]([OH:34])=[N:32][C:30]=1[OH:31]

参加物

反応物 4

HCID 297Methane

HCID 1176Urea

HCID 14798Sodium Hydroxide

HCID 11956655HCID 11956655、化合物

生成物 1

HCID 178518411HCID 178518411、化合物収率 75%

実験手順

10.0 g (64.0 mmol) of methylester 3-aminothiophene-2-carboxylate (I) and 19.0 g (31.60 mmol) of urea are mixed and melted for 2 hours at 200° C. After cooling, the reaction mixture is dissolved in 1 molar sodium hydroxide solution and decolorized with activated charcoal. It is filtered and the filtrate is cooled and acidified with 4M hydrochloric acid. The precipitate formed is suction filtered and dried. 8.03 g of product II (75%) is obtained as a powder.