Hydrochloric Acid → 870562-26-8
反応式
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([F:13])=[CH:5][CH:4]=1)#[N:2].[ClH:14]>C(O)C.[Pd]>[ClH:14].[F:13][C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]([CH2:1][NH2:2])=[CH:4][CH:5]=1参加物
5
実験手順
A solution of 1-cyano-4-fluoronapthalene (1.05 g, 6.12 mmol) and 1.5 mL of HCl (aq.) in absolute ethanol (50 mL) was stirred under a hydrogen atmosphere (balloon) with 10% palladium on carbon (0.20 g) for 16 hours. The catalyst was removed by filtration through Celite, and the filtrate concentrated under vacuum. The resulting solid was triturated with ether and collected by filtration to give the title compound (0.575 g, 44% yield) as an off white solid.
後処理
- customThe catalyst was removed by filtration through Celite
- concentrationthe filtrate concentrated under vacuum
- customThe resulting solid was triturated with ether
- filtrationcollected by filtration
出典と根拠
- ORDレコード
- ord-68aee97f0d9f4ec9b2a3d3c7715b29a2
- 出典データセット
- uspto-grants-2009_03
- 特許番号
- US07511037B2
反応ノート
読み込み中…