Water → Ethyl 4-(cyclohexylamino)-3-nitrobenzoate

HRID 1788404

反応式

HRID 1788404 の反応式
[CH2:1]([O:3][C:4](=[O:15])[C:5]1[CH:10]=[CH:9][C:8](Cl)=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1)[CH3:2].[CH:16]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1.O>C(#N)C>[CH2:1]([O:3][C:4](=[O:15])[C:5]1[CH:10]=[CH:9][C:8]([NH:22][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1)[CH3:2]

参加物

5

反応物 3

HCID 962WaterHCID 7965CyclohexylamineHCID 1268247Ethyl 4-chloro-3-nitrobenzoate

生成物 1

HCID 5298559Ethyl 4-(cyclohexylamino)-3-nitrobenzoate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of Compound 9 (22.96 g, 100 mmol), cyclohexylamine (15.31 g, 154 mmol) and TEA (13.57 g, 134 mmol) in 100 mL acetonitrile was refluxed overnight. The reaction mixture was poured into icy water and the precipitated crystals were collected by means of filtration, washed three times with water then was dried over phosphorous pentoxide in high vacuum to yield Compound 10.

後処理

  1. filtrationthe precipitated crystals were collected by means of filtration
  2. washwashed three times with water
  3. dry with materialthen was dried over phosphorous pentoxide in high vacuum

出典と根拠

ORDレコード
ord-f5e0bd8ff69a4e21abafde0eae58e9a5
出典データセット
uspto-grants-2009_03
特許番号
US07511145B2

関連ノート

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