Ethyl 4-(cyclohexylamino)-3-nitrobenzoate → Ferrostatin-1

HRID 1788405

反応式

HRID 1788405 の反応式
[CH2:1]([O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[C:7]([N+:18]([O-])=O)[CH:6]=1)[CH3:2]>C(OCC)(=O)C.CO.[Pd]>[CH2:1]([O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][CH:12]2[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)=[C:7]([NH2:18])[CH:6]=1)[CH3:2]

参加物

5

反応物 1

HCID 5298559Ethyl 4-(cyclohexylamino)-3-nitrobenzoate

生成物 1

HCID 4068248Ferrostatin-1

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 5.84 g (20 mmol) of Compound 10 in 50 mL ethyl acetate and 30 mL methanol, 100 mg of 10% Pd/C was added, and the mixture was hydrogenated at 30 psi for 6 h. The catalyst was removed by filtration through a pad of Celite, the solvent was evaporated to dryness resulting in a dark purple solid which was recrystallized from ether-hexane. The mother liquid was evaporated, and the resulting solid was suspended in hexane and filtered to give additional yield of Compound 11

後処理

  1. customThe catalyst was removed by filtration through a pad of Celite
  2. customthe solvent was evaporated to dryness
  3. customresulting in a dark purple solid which
  4. customwas recrystallized from ether-hexane
  5. customThe mother liquid was evaporated
  6. filtrationfiltered

出典と根拠

ORDレコード
ord-29174407198c49d7a92d8befd421f1d3
出典データセット
uspto-grants-2009_03
特許番号
US07511145B2

関連ノート

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