Diisopropylethylamine → 3-({2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carbonyl}-amino)-4-cyclohexylamino-benzoic acid ethyl ester

HRID 1788417

反応式

HRID 1788417 の反応式
[Cl:1][C:2]1[CH:33]=[CH:32][C:5]([C:6]2[C:11]([C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][CH:16]=[C:17]([C:22](O)=[O:23])[CH:18]=4)[N:13]=3)=[CH:10][C:9]([C:25]([N:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)=[O:26])=[CH:8][CH:7]=2)=[CH:4][CH:3]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.[CH2:67]([O:69][C:70](=[O:85])[C:71]1[CH:76]=[CH:75][C:74]([NH:77][CH:78]2[CH2:83][CH2:82][CH2:81][CH2:80][CH2:79]2)=[C:73]([NH2:84])[CH:72]=1)[CH3:68]>CN(C=O)C>[CH2:67]([O:69][C:70](=[O:85])[C:71]1[CH:76]=[CH:75][C:74]([NH:77][CH:78]2[CH2:79][CH2:80][CH2:81][CH2:82][CH2:83]2)=[C:73]([NH:84][C:22]([C:17]2[CH:18]=[C:19]3[C:14](=[CH:15][CH:16]=2)[N:13]=[C:12]([C:11]2[C:6]([C:5]4[CH:32]=[CH:33][C:2]([Cl:1])=[CH:3][CH:4]=4)=[CH:7][CH:8]=[C:9]([C:25]([N:27]4[CH2:31][CH2:30][CH2:29][CH2:28]4)=[O:26])[CH:10]=2)[CH:21]=[CH:20]3)=[O:23])[CH:72]=1)[CH3:68]

参加物

6

反応物 4

HCID 81531DiisopropylethylamineHCID 4068248Ferrostatin-1HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 576029872-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carboxylic acid

生成物 1

HCID 576030893-({2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carbonyl}-amino)-4-cyclohexylamino-benzoic acid ethyl ester

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Compound 24 (270 mg, 0.59 mmol) in 4 mL of DMF was activated with 246.6 mg (0.65 mmol) of HATU and 226 μL (1.30 mmol) of DIEA at room temperature for 15 minutes. Compound 11 (170 mg, 0.65 mmol) was added as solid and the mixture was stirred overnight. The DMF was evaporated; the remaining oil was solidified by trituration with water. The solid Compound 25 was filtered off, dried and used without further purification. MS: 701.34 (M+H+).

後処理

  1. customThe DMF was evaporated
  2. filtrationThe solid Compound 25 was filtered off
  3. customdried
  4. customused without further purification

出典と根拠

ORDレコード
ord-dc2f37d7126f464e98b6500b96223c44
出典データセット
uspto-grants-2009_03
特許番号
US07511145B2

関連ノート

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