Benzil → 1-Cyclohexyl-2-(2,3-diphenylquinoxalin-6-yl)benzimidazole-5-carboxylic acid

HRID 1788450ノート

反応式

HRID 1788450 の反応式
[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:19]2[CH:24]=[CH:23][C:22]([NH2:25])=[C:21]([NH2:26])[CH:20]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:27]1([C:33]([C:35]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=O)=O)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:19]2[CH:20]=[C:21]3[C:22](=[CH:23][CH:24]=2)[N:25]=[C:35]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:33]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[N:26]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 8651BenzilHCID 689222991-Cyclohexyl-2-(3,4-diaminophenyl)-1H-benzimidazole-5-carboxylic Acid

生成物 1

HCID 52760271-Cyclohexyl-2-(2,3-diphenylquinoxalin-6-yl)benzimidazole-5-carboxylic acid

実験手順

A solution of 100 mg (0.29 mmol) of Compound 406b and 74 mg (0.35 mmol) of benzil was stirred at room temperature overnight. The solvent was evaporated and the residue was purified on preparative HPLC yielding 10 mg.

後処理

  1. customThe solvent was evaporated
  2. customthe residue was purified on preparative HPLC
  3. customyielding 10 mg

出典と根拠

ORDレコード
ord-afe93530b68c4c44afbddeeb0e91daec
出典データセット
uspto-grants-2009_03
特許番号
US07511145B2

反応ノート

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