Hydrochloric Acid → Methanesulfonamide, N-[4-(2-chloroacetyl)phenyl]-

HRID 1789460

反応式

HRID 1789460 の反応式
[C:1]1([NH:7][S:8]([CH3:11])(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:12][CH2:13][C:14](Cl)=[O:15].[Cl-].[Al+3].[Cl-].[Cl-].Cl>C(Cl)Cl>[Cl:12][CH2:13][C:14]([C:4]1[CH:3]=[CH:2][C:1]([NH:7][S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=1)=[O:15]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6577Chloroacetyl chlorideHCID 70970Methanesulfonamide, N-phenyl-HCID 6451240Aluminum(III) Chloride

生成物 1

HCID 116629Methanesulfonamide, N-[4-(2-chloroacetyl)phenyl]-

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
-10 °C

実験手順

In a flask containing 128.4 g (0.75 mole) of N-phenylmethanesulfonamide, 169.5 g (1.50 mole) of chloroacetyl chloride in 1 L of methylene chloride under an atmosphere of nitrogen and cooled to about -10° C. add 300 g (2.25 mole) of aluminum chloride. Stir the resulting mixture for about 16 hours. Pour the reaction mixture onto 2 Kg of ice containing 600 mL of concentrated hydrochloric acid. Collect the precipitate and wash with methanol (3×300 mL) and dry in vacuo to give the title compound.

後処理

  1. customCollect the precipitate
  2. washwash with methanol (3×300 mL)
  3. customdry in vacuo

出典と根拠

ORDレコード
ord-03a078946e734c8a99d29a0b27efcafc
出典データセット
uspto-grants-1987_08
特許番号
US04689341

関連ノート

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