Methyl iodide → 3-Methyl-1-[2-[4-((methylsulfonyl)amino)phenyl]ethyl]-1H-imidazolium iodide

HRID 1789480ノート

反応式

HRID 1789480 の反応式
[N:1]1([CH2:6][CH2:7][C:8]2[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[I:19][CH3:20]>CO>[I-:19].[CH3:20][N:3]1[CH:4]=[CH:5][NH+:1]([CH2:6][CH2:7][C:8]2[CH:9]=[CH:10][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:12][CH:13]=2)[CH2:2]1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 137633971-[2-[4-[(Methylsulfonyl)amino]phenyl]ethyl]-1H-imidazole

生成物 1

HCID 704378243-Methyl-1-[2-[4-((methylsulfonyl)amino)phenyl]ethyl]-1H-imidazolium iodide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Heat a mixture of 5 g (0.019 mole) of N-[4-[2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide, 5 mL of iodomethane and 25 mL of methanol in a pressure tube at 75° C. for about 24 hours. Cool the mixture to room temperature and remove the solvents in vacuo. Slurry the residue in acetone (50 mL) and filter and wash with acetone (100 mL). Drying provides the title compound, which may be recrystallized from methanol.

後処理

  1. temperatureHeat
  2. customremove the solvents in vacuo
  3. filtrationfilter
  4. washwash with acetone (100 mL)
  5. customDrying

出典と根拠

ORDレコード
ord-fe6bc469579849c190d98ec39f6d6c77
出典データセット
uspto-grants-1987_08
特許番号
US04689341

反応ノート

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