Hydrogen Bromide → 2-(1-hydroxy-naphthalen-2-yl)-1-methylethylamine Hydrochloride

HRID 1790298ノート

反応式

HRID 1790298 の反応式
[ClH:1].C[O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH2:14][CH:15]([NH2:17])[CH3:16].Br>>[ClH:1].[OH:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6][C:5]=1[CH2:14][CH:15]([NH2:17])[CH3:16]

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 220417522-(1-Methoxy-naphthalen-2-yl)-1-methylethylamine hydrochloride

生成物 1

HCID 220417562-(1-hydroxy-naphthalen-2-yl)-1-methylethylamine Hydrochloride

実験手順

A solution of 2-(1-methoxy-naphthalen-2-yl)-1-methylethylamine hydrochloride (0.1 g, 0.40 mmol) and HBr 48% was refluxed for 3 h. The reaction mixture was concentrated under vacuum, the residue was washed with hexane and ether and then collected by filtration: 1H NMR (DMSO-d) δ 1.14 (d, 3H, CH3), 2.86–3.11 (m, 2H, CH2), 3.47 (m, 1H, CH), 7.25 (d, 1H, Ar—H), 7.47 (m, 2H, Ar—H), 7.83 (m, 4H, 1Ar—H+NH3+); 8.24 (m, 1H, Ar—H), 9.36 (s, OH); MS 202 (M+1). Analysis. Calcd. for C13H15NO.HBr.0.5 H2O: C, 53.62; H, 5.88; N, 4.81. Found: C, 53.53; H, 5.56; N, 4.77.

後処理

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. washthe residue was washed with hexane and ether
  3. filtrationcollected by filtration

出典と根拠

ORDレコード
ord-cde8aa8f36f64caa85bf895d0748e51a
出典データセット
uspto-grants-2006_07
特許番号
US07071225B2

反応ノート

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