1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-[(isobutylcarbamoyl)methyl]indoline → 1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-(ethylcarbamoylmethyl)indole

HRID 1790501ノート

反応式

HRID 1790501 の反応式
[F:1][C:2]1[CH:32]=[CH:31][C:5]([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][C:24](=[O:30])[NH:25][CH2:26][CH:27](C)C)[CH:21]=4)[CH2:16][CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:7][N:8]2[CH2:9][CH2:10][CH:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][C:24](=[O:30])[NH:25][CH2:26][CH3:27])[CH:21]=4)[CH:16]=[CH:15]3)[CH2:12][CH2:13]2)=[CH:31][CH:32]=1

参加物

4

反応物 1

HCID 220379731-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-[(isobutylcarbamoyl)methyl]indoline

生成物 1

HCID 220383791-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-(ethylcarbamoylmethyl)indole収率 76.7%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

反応条件

温度
50 °C

実験手順

A suspension of 1-[1-(4-fluorophenethyl)piperidin-4-yl]-6-[(isobutylcarbamoyl)methyl]indoline (0.07 g) obtained in Example 152 and active manganese dioxide (0.07 g) in chloroform (30 ml) was vigorously stirred at 50° C. overnight. Then the reaction mixtures were filtered through celite and the residue was washed with chloroform. After concentrating the filtrate under reduced pressure, the residue was recrystallized from chloroform/hexane to give the title compound (0.05 g) as a white powder (yield: 70.0%).

後処理

  1. customThen the reaction mixtures
  2. filtrationwere filtered through celite
  3. washthe residue was washed with chloroform
  4. concentrationAfter concentrating the filtrate under reduced pressure
  5. customthe residue was recrystallized from chloroform/hexane

出典と根拠

ORDレコード
ord-7ba06a0745eb45d59643d5c89d39e192
出典データセット
uspto-grants-2006_07
特許番号
US07071201B2

反応ノート

読み込み中…