Methyl iodide → Benzoic Acid
反応式
NC1C=C(C=CC=1NC)OC1C=CN=C(C(NC)=O)C=1.N([C:24]1[CH:32]=[CH:31][C:27]([C:28]([OH:30])=[O:29])=[CH:26][CH:25]=1)=C=S.IC>CO>[C:28]([OH:30])(=[O:29])[C:27]1[CH:31]=[CH:32][CH:24]=[CH:25][CH:26]=1参加物
5
反応条件
- 温度
- 60 °C
実験手順
To {4-[3-amino-4-(methylamino)phenoxy](2-pyridyl)}-N-methylcarboxamide (1 eq) in methanol was added 4-isothiocyanatobenzoic acid (1 eq) and stirred at 60° C. for 3 h. To it was then added iodomethane (1 eq) and heated to 60° C. for 3 h. and concentrated the solvent and purified on silica gel to yield 4-({1-methyl-5-[2-(N-methylcarbamoyl)(4-pyridyloxy))]benzimidazol-2-yl}amino)benzoic acid. MS: MH+=417.
後処理
- concentrationconcentrated the solvent
- custompurified on silica gel
出典と根拠
- ORDレコード
- ord-4993b6bd45dd4b758422db41b7abca7f
- 出典データセット
- uspto-grants-2006_07
- 特許番号
- US07071216B2
反応ノート
読み込み中…