Ethanol → 4-(3-Pyrrolidinylpropoxy)benzene-1,2-diamine
反応式
CO[C:3]1[CH:19]=[C:18]([NH:20]C)[C:17]([N+:22]([O-])=O)=[CH:16][C:4]=1[O:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]([C:12](NC)=O)C=1.[CH3:25][CH2:26]O>[Pd]>[N:9]1([CH2:10][CH2:11][CH2:6][O:5][C:4]2[CH:16]=[C:17]([NH2:22])[C:18]([NH2:20])=[CH:19][CH:3]=2)[CH2:8][CH2:12][CH2:26][CH2:25]1参加物
4
実験手順
To a solution 2-Nitro-4-(3-pyrrolidinylpropoxy)phenylamine 1 in EtOH, Pd/C (0.1 eq) is added. The reaction vessel is repeatedly purged (×3) with nitrogen, and then stirred under a hydrogen atmosphere for 18 h. The product is filtered through a Celite plug, and the plug washed with 25 mL of EtOH, to yield 2. LCMS 236.2 Rt 0.94 min.
後処理
- customThe reaction vessel is repeatedly purged (×3) with nitrogen
- filtrationThe product is filtered through a Celite plug
- washthe plug washed with 25 mL of EtOH
- customto yield 2
出典と根拠
- ORDレコード
- ord-d83a7c5eff9f4444938f5ef737900e22
- 出典データセット
- uspto-grants-2006_07
- 特許番号
- US07071216B2
反応ノート
読み込み中…