Trifluoroacetic acid → 5-carboxymethoxy-1H-indole-2-carboxylic acid ethyl ester

HRID 1790898

反応式

HRID 1790898 の反応式
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([O:15][CH2:16][C:17]([O:19]C(C)(C)C)=[O:18])=[CH:10][CH:9]=2)=[O:5])[CH3:2].FC(F)(F)C(O)=O>ClCCl>[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([O:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 695874395-tert-butoxycarbonylmethoxy-1H-indole-2-carboxylic acid ethyl ester

生成物 1

HCID 695866655-carboxymethoxy-1H-indole-2-carboxylic acid ethyl ester収率 101.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 5-tert-butoxycarbonylmethoxy-1H-indole-2-carboxylic acid ethyl ester (2 g, 6 mmol) and trifluoroacetic acid (8 mL) in dichloromethane (8 mL) was stirred at room temperature for 2 hours. The reaction was concentrated to give 1.6 g (97%) of 5-carboxymethoxy-1H-indole-2-carboxylic acid ethyl ester as a light brown solid.

後処理

  1. concentrationThe reaction was concentrated

出典と根拠

ORDレコード
ord-1cd0dafad4d04a1f958e81fb95affc08
出典データセット
uspto-grants-2006_07
特許番号
US07071332B2

関連ノート

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