Benzaldehyde → 2-[2-Amino-4-(benzylamino)phenoxy]ethanol

HRID 1791085

反応式

HRID 1791085 の反応式
[NH2:1][C:2]1[CH:11]=[C:10]([NH2:12])[CH:9]=[CH:8][C:3]=1[O:4][CH2:5][CH2:6][OH:7].[CH:13](=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.B.O1CCCC1>CO.O1CCCC1>[NH2:1][C:2]1[CH:11]=[C:10]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:9]=[CH:8][C:3]=1[O:4][CH2:5][CH2:6][OH:7]

参加物

6

反応物 3

HCID 240BenzaldehydeHCID 479332-(2,4-Diaminophenoxy)ethanolHCID 2723981Borane;tetrahydrofuran

生成物 1

HCID 220265492-[2-Amino-4-(benzylamino)phenoxy]ethanol

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

2.66 g (10 mmol) of 2-(2,4-diaminophenoxy)ethanol and 1.06 g (10 mmol) of benzaldehyde were dissolved in methanol (dried over molecular sieve). After addition of 10 mg of molecular sieve, the reaction mixture was allowed to agitate 7 hours. Then, 20 mL of a solution of borane-tetrahydrofuran com-plex (1 M in tetrahydrofuran) was added at 0° C., and the reaction mixture was allowed to agitate one hour at room temperature. At the end of the reaction, the reaction mixture was filtered and hydrolyzed. The precipitate was filtered off, washed with water and then dried.

後処理

  1. additionAfter addition of 10 mg of molecular sieve
  2. stirringto agitate one hour at room temperature
  3. customAt the end of the reaction
  4. filtrationthe reaction mixture was filtered
  5. filtrationThe precipitate was filtered off
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-07a7655d22c44b9194cd699db25c9830
出典データセット
uspto-grants-2006_07
特許番号
US07074243B2

関連ノート

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