Nitric Acid → 2-(4-Bromo-3-nitro-phenyl)-3-(trifluoromethyl)-pyridine
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1.[N+:18]([O-])([OH:20])=[O:19]>OS(O)(=O)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([C:14]([F:17])([F:15])[F:16])=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:6][C:7]=1[N+:18]([O-:20])=[O:19]参加物
4
実験手順
To a solution of 2-(4-bromophenyl)-3-(trifluoromethyl)-pyridine (0.93 mmol) in H2SO4 (4 mL) cautiously add fuming HNO3 (2 ml). Stir the mixture 30 minutes at room temperature. Pour the mixture onto ice-water (20 mL) and collect the precipitate. Dissolve the precipitate in EtOAc and neutralize with saturated NaHCO3, dry over Na2SO4, concentrate under vacuum to obtain 2-(4-bromo-3-nitro-phenyl)-3-(trifluoromethyl)-pyridine.