Triethylamine → 3-Fluoro-7-methoxyquinoline
反応式
Cl[C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:4](=[CH:5][C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=1.C(N(CC)CC)C>[Pd].C(O)C>[F:12][C:11]1[CH:2]=[N:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[C:6]([O:13][CH3:14])[CH:5]=2参加物
5
実験手順
A mixture of 2-chloro-3-fluoro-7-methoxyquinoline (310 mg, 1.47 mmol), triethylamine (310 mg, 0.4 ml, 3.07 mmol) and 10% palladium on activated charcoal (50 mg) in dry ethanol (5 ml) was stirred under hydrogen gas at ambient temperature for 24 hours. The mixture was then filtered through celite. The celite was washed with methanol and the solvent was removed by evaporation from the combined filtrates. The crude material was purified by chromatography on silica, eluting with 10% ethyl acetate in isohexane to give 3-fluoro-7-methoxyquinoline (130 mg, 54%).
後処理
- filtrationThe mixture was then filtered through celite
- washThe celite was washed with methanol
- customthe solvent was removed by evaporation from the combined filtrates
- customThe crude material was purified by chromatography on silica
- washeluting with 10% ethyl acetate in isohexane
出典と根拠
- ORDレコード
- ord-47c36ea540f04f7688920621e4f1f72a
- 出典データセット
- uspto-grants-2006_07
- 特許番号
- US07074800B1
反応ノート
読み込み中…