2-Amino-o-cresol → 3-t-Butoxycarbonylamino-2-methylphenol

HRID 1791852

反応式

HRID 1791852 の反応式
[NH2:1][C:2]1[C:3]([CH3:9])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[C:10]([O:14][C:15](=O)[O:16]C(C)(C)C)([CH3:13])([CH3:12])[CH3:11]>C1COCC1>[C:10]([O:14][C:15]([NH:1][C:2]1[C:3]([CH3:9])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1)=[O:16])([CH3:13])([CH3:12])[CH3:11]

参加物

4

反応物 2

HCID 1044482-Amino-o-cresolHCID 10219638Carbonic acid, bis(1,1-dimethylethyl) ester

生成物 1

HCID 220334873-t-Butoxycarbonylamino-2-methylphenol収率 69%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

3-Amino-2-methylphenol (2.0 g; 16 mmol) and di-t-butylcarbonate were dissolved in THF (20 mL) and refluxed overnight. Evaporation of the solvent followed by flash chromatography (SiO2; EtOAc 5–30% in isohexane) afforded 2.48 g (69%) of the sub-title compound.

後処理

  1. temperaturerefluxed overnight
  2. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-7d57a165596141cbaf972e1129adb4f6
出典データセット
uspto-grants-2006_07
特許番号
US07074820B2

関連ノート

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