Allyl bromide → 7-Allyl-8-chloro-3-methyl-3,7-dihydropurine-2,6-dione

HRID 1791993ノート

反応式

HRID 1791993 の反応式
[Cl:1][C:2]1[NH:10][C:9]2[C:8](=[O:11])[NH:7][C:6](=[O:12])[N:5]([CH3:13])[C:4]=2[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:20](Br)[CH:21]=[CH2:22]>CN(C)C=O.C(OCC)(=O)C.O>[CH2:22]([N:10]1[C:9]2[C:8](=[O:11])[NH:7][C:6](=[O:12])[N:5]([CH3:13])[C:4]=2[N:3]=[C:2]1[Cl:1])[CH:21]=[CH2:20]

参加物

7

反応物 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 126175848-chloro-3-methyl-2,3,6,9-tetrahydro-1H-purine-2,6-dione

生成物 1

HCID 220295197-Allyl-8-chloro-3-methyl-3,7-dihydropurine-2,6-dione

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

8-Chloro-3-methyl-3,7-dihydropurine-2,6-dione (868 mg) and potassium carbonate (628 mg) were suspended in N,N-dimethylformamide (10 ml), and allyl bromide was added dropwise thereto while cooling on ice. After stirring the reaction mixture at room temperature for 17 hours, the resulting white suspension was diluted with ethyl acetate (30 ml) and water (4 ml), and was filtered to give a white solid. The solid was washed with water and ethyl acetate to give 797 mg of the title compound.

後処理

  1. temperaturewhile cooling on ice
  2. filtrationwas filtered
  3. customto give a white solid
  4. washThe solid was washed with water and ethyl acetate

出典と根拠

ORDレコード
ord-eba40e1b03a04e9bac81fafb421d9fb6
出典データセット
uspto-grants-2006_07
特許番号
US07074798B2

反応ノート

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