Trifluoroacetic acid → [7-(2-Butynyl)-2,6-dioxo-8-(piperazin-1-yl)-1,2,6,7-tetrahydropurin-3-yl] acetic acid methyl ester trifluoroacetate

HRID 1792063ノート

反応式

HRID 1792063 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:22]([CH2:23][C:24]#[C:25][CH3:26])[C:21]3[C:20](=[O:27])[NH:19][C:18](=[O:28])[N:17]([CH2:29][C:30]([O:32][CH3:33])=[O:31])[C:16]=3[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]>>[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37].[CH3:33][O:32][C:30](=[O:31])[CH2:29][N:17]1[C:16]2[N:15]=[C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[N:22]([CH2:23][C:24]#[C:25][CH3:26])[C:21]=2[C:20](=[O:27])[NH:19][C:18]1=[O:28]

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 235369464-[7-(2-Butynyl)-3-methoxycarbonylmethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 69566880[7-(2-Butynyl)-2,6-dioxo-8-(piperazin-1-yl)-1,2,6,7-tetrahydropurin-3-yl] acetic acid methyl ester trifluoroacetate

実験手順

4-[7-(2-Butynyl)-3-methoxycarbonylmethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylic acid tert-butyl ester (13 mg) was dissolved in trifluoroacetic acid (0.5 ml), and the solution was stirred at room temperature for 30 minutes. After the solvent was removed by distillation, a half of the residue was purified by HPLC with a reversed phase system column using water-acetonitrile-trifluoroacetic acid system as elution solvent to give 2.4 mg of the title compound.

後処理

  1. customAfter the solvent was removed by distillation
  2. customa half of the residue was purified by HPLC with a reversed phase system column
  3. washas elution solvent

出典と根拠

ORDレコード
ord-d474136064c3418089ffd13c09f942de
出典データセット
uspto-grants-2006_07
特許番号
US07074798B2

反応ノート

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