2-(5-Bromo-2-pyridinylamino)-1-cyanoethyl toluene-4-sulfonate → 6-Bromo-2,3-dihydroimidazo[1,2-a]pyridine-3-carbonitrile

HRID 1792458ノート

反応式

HRID 1792458 の反応式
C1(C)C=CC(S(O[CH:11]([C:21]#[N:22])[CH2:12][NH:13][C:14]2[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][N:15]=2)(=O)=O)=CC=1>C(#N)C>[Br:20][C:17]1[CH:18]=[CH:19][C:14]2[N:15]([CH:11]([C:21]#[N:22])[CH2:12][N:13]=2)[CH:16]=1

参加物

3

反応物 1

HCID 235374122-(5-Bromo-2-pyridinylamino)-1-cyanoethyl toluene-4-sulfonate

生成物 1

HCID 220317966-Bromo-2,3-dihydroimidazo[1,2-a]pyridine-3-carbonitrile収率 88.7%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

7.64 g of 2-(5-bromo-2-pyridinylamino)-1-cyanoethyl toluene-4-sulfonate was dissolved in 76 mL acetonitrile, and the mixture was heated for 15 hours under reflux. After the solvent was removed, an aqueous saturated sodium bicarbonate was poured into the reaction product which was then extracted with dichloromethane, and the organic layer was dried over anhydrous sodium sulfate and filtered through NH silica gel. The solvent was removed, whereby 3.83 g of the title compound (yellow solid) was obtained.

後処理

  1. temperaturethe mixture was heated for 15 hours
  2. temperatureunder reflux
  3. customAfter the solvent was removed
  4. additionan aqueous saturated sodium bicarbonate was poured into the reaction product which
  5. extractionwas then extracted with dichloromethane
  6. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  7. filtrationfiltered through NH silica gel
  8. customThe solvent was removed

出典と根拠

ORDレコード
ord-fa9d214665694c878069c3dfffe8226b
出典データセット
uspto-grants-2006_07
特許番号
US07074801B1

反応ノート

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