Methylamine → 5-(6-Bromoquinazolin-4-yl)-thiophen-2-sulfonic acid methylamide

HRID 1792492ノート

反応式

HRID 1792492 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[C:12]1[S:16][C:15]([S:17](Cl)(=[O:19])=[O:18])=[CH:14][CH:13]=1.[CH3:21][NH2:22]>O1CCCC1>[CH3:21][NH:22][S:17]([C:15]1[S:16][C:12]([C:5]2[C:4]3[C:9](=[CH:10][CH:11]=[C:2]([Br:1])[CH:3]=3)[N:8]=[CH:7][N:6]=2)=[CH:13][CH:14]=1)(=[O:19])=[O:18]

参加物

4

反応物 2

HCID 6329MethylamineHCID 220314245-(6-Bromoquinazolin-4-yl)-thiophen-2-sulfonyl chloride

生成物 1

HCID 235375525-(6-Bromoquinazolin-4-yl)-thiophen-2-sulfonic acid methylamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

800 mg of 5-(6-bromoquinazolin-4-yl)-thiophen-2-sulfonyl chloride (compound in Production Example 377) was dissolved in 15 mL tetrahydrofuran, and 1.78 mL methylamine was added thereto and stirred at room temperature for 1 hour. The solvent was removed, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane), to give 752 mg of the title compound (pale skin-colored crystals).

後処理

  1. customThe solvent was removed
  2. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-a7ce280c114f486cab7c929a87e21d54
出典データセット
uspto-grants-2006_07
特許番号
US07074801B1

反応ノート

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