Hydrazine hydrate (1:1) → 6-Bromoquinazoline-4-carboxylic acid hydrazide

HRID 1792500ノート

反応式

HRID 1792500 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[C:12]([O:14]C)=O.O.[NH2:17][NH2:18]>CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[C:12]([NH:17][NH2:18])=[O:14]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 22031300Methyl 6-bromoquinazoline-4-carboxylate

生成物 1

HCID 235376576-Bromoquinazoline-4-carboxylic acid hydrazide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 961 mg methyl 6-bromoquinazoline-4-carboxylate (compound in Production Example 413), 0.9 mL hydrazine monohydrate and 70 mL methanol was stirred at room temperature for 30 minutes, and the precipitated crystals were collected by filtration. The filtrate was evaporated to give additional crystals. The title compound, 838 mg in total, was obtained as pale yellow crystals.

後処理

  1. filtrationthe precipitated crystals were collected by filtration
  2. customThe filtrate was evaporated
  3. customto give additional crystals

出典と根拠

ORDレコード
ord-b96e73a1e56e4329afd9d3fefcac5524
出典データセット
uspto-grants-2006_07
特許番号
US07074801B1

反応ノート

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