Trifluoroacetic acid → N,N-Dimethyl-4-[6-(3-methyl-1H-4-pyrazolyl)-4-quinolyl]-1-piperazine sulfonamide

HRID 1792569ノート

反応式

HRID 1792569 の反応式
[CH3:1][N:2]([CH3:47])[S:3]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([C:22]4[C:23]([CH3:46])=[N:24][N:25](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:26]=4)[CH:20]=3)[N:15]=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)(=[O:5])=[O:4].FC(F)(F)C(O)=O>>[CH3:1][N:2]([CH3:47])[S:3]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([C:22]4[C:23]([CH3:46])=[N:24][NH:25][CH:26]=4)[CH:20]=3)[N:15]=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)(=[O:4])=[O:5]

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 23537796N,N-dimethyl-4-[6-(3-methyl-1-trityl-1H-pyrazolyl)-4-quinolyl]-1-piperazine sulfonamide

生成物 1

HCID 178434512N,N-Dimethyl-4-[6-(3-methyl-1H-4-pyrazolyl)-4-quinolyl]-1-piperazine sulfonamide収率 69.4%

実験手順

37 mg N,N-dimethyl-4-[6-(3-methyl-1-trityl-1H-pyrazolyl)-4-quinolyl]-1-piperazine sulfonamide obtained in Example 183 and 0.2 mL trifluoroacetic acid were reacted in the same manner as in Example 165, to give 16 mg of the title compound as pale yellow crystals.

出典と根拠

ORDレコード
ord-10d1169e32a1472798369eb75577d4b3
出典データセット
uspto-grants-2006_07
特許番号
US07074801B1

反応ノート

読み込み中…