HCID 23537502、化合物 → HCID 178488643、化合物

HRID 1792631ノート

反応式

HRID 1792631 の反応式
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]4[C:20]([C:43]([F:46])([F:45])[F:44])=[N:21][N:22](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:23]=4)[CH:17]=3)[N:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=1>FC(F)(F)C(O)=O>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]4[C:20]([C:43]([F:45])([F:44])[F:46])=[N:21][NH:22][CH:23]=4)[CH:17]=3)[N:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

参加物

3

反応物 1

HCID 23537502HCID 23537502、化合物

生成物 1

HCID 178488643HCID 178488643、化合物収率 86.7%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A mixture of 210 mg 4-(6-methoxypyridin-3-yl)-6-(3-trifluoromethyl-1-trityl-1H-pyrazol-4-yl) quinoline obtained in Example 1063 and 10 mL trifluoroacetic acid was stirred at room temperature for 1 hour. The trifluoroacetic acid was evaporated, and an aqueous saturated sodiumbicarbonate solution was added to the residue which was then extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was purified by silica gel column chromatography to give 110 mg of the title compound as a colorless solid.

後処理

  1. customThe trifluoroacetic acid was evaporated
  2. additionan aqueous saturated sodiumbicarbonate solution was added to the residue which
  3. extractionwas then extracted with ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated
  7. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-5598c05e55684dffb547e8df1b32f1b8
出典データセット
uspto-grants-2006_07
特許番号
US07074801B1

反応ノート

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