Oxalyl chloride → HCID 22024981、化合物

HRID 1792790ノート

反応式

HRID 1792790 の反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].C([C:10]1[CH:14]=[CH:13][N:12]([C:15]2[CH:24]=[CH:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]=2)[C:11]=1C)(O)=O>ClCCl>[ClH:4].[Cl:4][C:2]([C:1]1[CH:10]=[CH:11][N:12]([C:15]2[CH:24]=[CH:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]=2)[C:13]=1[CH3:14])=[O:3]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 220249772-Methyl-1-(quinolin-2-yl)-1H-pyrrole-3-carboxylic acid

生成物 1

HCID 22024981HCID 22024981、化合物収率 104.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
20 °C

実験手順

10 mL (114.2 mmol) of oxalyl chloride are added at 20° C. under an argon atmosphere to 1.8 g (6.25 mmol) of 3-carboxy-2-methyl-1-(quinol-2-yl)-1H-pyrrole dissolved in 120 mL of dichloromethane. After stirring at 20° C. for 16 hours, the reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa) to give 2 g of 3-chlorocarbonyl-2-methyl-1-(quinol-2-yl)-1H-pyrrole hydrochloride in the form of a beige-coloured solid which is used directly in the following step.

後処理

  1. concentrationthe reaction mixture is concentrated to dryness under reduced pressure (2.7 kPa)

出典と根拠

ORDレコード
ord-52db778ef2ac4a7ab922a2d06b8de288
出典データセット
uspto-grants-2006_07
特許番号
US07078414B2

反応ノート

読み込み中…