p-Toluenesulfonic acid → HCID 22025412、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:11]([NH:13][CH2:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[O:12])[C:5](=[CH:9][CH:10]=1)[C:6](O)=[O:7].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:11](=[O:12])[N:13]([CH2:14][CH2:15][C:16]([F:19])([F:18])[F:17])[C:6](=[O:7])[C:5]2=[CH:9][CH:10]=1参加物
4
実験手順
A mixture of 5.0 g of 4-chloro-N-(3,3,3-trifluoropropyl)phthalamic acid and 30 mg of para-toluenesulfonic acid in 100 cm3 of toluene is refluxed with stirring for 7 hours. The reaction mixture is then concentrated to dryness under reduced pressure. 4.2 g of 4-chloro-N-(3,3,3-trifluoropropyl)phthalimide are thus obtained, Rf=0.5 (thin layer chromatography on silica gel, eluent: diisopropyl ether. Mass spectrum: DCI: m/e 278.