Thionyl Chloride → HCID 22024658、化合物

HRID 1793084ノート

反応式

HRID 1793084 の反応式
[Br:1][C:2]1[C:3]([NH:8][CH:9]([CH2:12][CH3:13])[CH2:10]O)=[N:4][CH:5]=[N:6][CH:7]=1.S(Cl)(Cl)=O>C1(C)C(C)=CC=CC=1>[Br:1][C:2]1[C:3]2[N:4]([CH2:10][CH:9]([CH2:12][CH3:13])[N:8]=2)[CH:5]=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 22024679HCID 22024679、化合物

生成物 1

HCID 22024658HCID 22024658、化合物収率 98.1%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

反応条件

温度
100 °C

実験手順

2-[(5-Bromo-4-pyrimidinyl)amino]-1-butanol (3.3 g) was dissolved in xylene (27 mL), then thionyl chloride (4.9 mL) was added thereto, and the mixture was heated under stirring at 100° C. for 1 day. The precipitated crystals were collected by filtration and suspended in a 1M aqueous sodium carbonate solution. This mixture was extracted with dichloromethane to give the crude title compound (3.0 g) as an orange oil. This title compound was used in the next reaction without purification.

後処理

  1. temperaturethe mixture was heated
  2. filtrationThe precipitated crystals were collected by filtration
  3. extractionThis mixture was extracted with dichloromethane

出典と根拠

ORDレコード
ord-5ce564191dcc48cfa674d17d783155ab
出典データセット
uspto-grants-2006_07
特許番号
US07078405B2

反応ノート

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