6-Methylquinoline → 6-(Bromomethyl)quinoline
反応式
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.C1C(=O)N([Br:19])C(=O)C1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:19][CH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2参加物
5
実験手順
To a solution of 6-methylquinoline (2.15 g, 15.0 mmol) in CCl4 (30 mL) was added NBS (2.92 g, 16.5 mmol) and benzoyl peroxide (BP, 0.36 g, 1.5 mmol) at room temperature. The mixture was heated at reflux for 2 hours. After cooling, the mixture was evaporated under vacuum to give a yellow solid, which was extracted with Petroleum Ether (30 mL×5). The extracts were concentrated under vacuum to give crude 6-bromomethylquinoline (1.8 g), which was used directly in the next step.
後処理
- temperatureThe mixture was heated
- temperatureat reflux for 2 hours
- temperatureAfter cooling
- customthe mixture was evaporated under vacuum
- customto give a yellow solid, which
- extractionwas extracted with Petroleum Ether (30 mL×5)
- concentrationThe extracts were concentrated under vacuum
出典と根拠
- ORDレコード
- ord-bdab12189dab47a7a6bf709c59d3a49b
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07741321B2
反応ノート
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