Ethyl Bromide → 3-(Naphthalen-2-yloxy)propan-1-amine

HRID 1793494ノート

反応式

HRID 1793494 の反応式
COC1C=CC([NH:9][CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)=CC=1.C(Br)C>CC(C)=O>[CH:15]1[C:16]2[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:22]=[CH:23][C:14]=1[O:13][CH2:12][CH2:11][CH2:10][NH2:9]

参加物

4

反応物 2

HCID 6332Ethyl BromideHCID 9839556(4-Methoxyphenyl)-(3-(naphthalen-2-yloxy)propyl)amine

生成物 1

HCID 167907513-(Naphthalen-2-yloxy)propan-1-amine

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of N-(4-methoxyphenyl)-[3-(naphthalen-2-yloxy)propyl]amine (0.5 gm, 0.002 mole) and ethyl bromide(0.52 ml, 0.003 mole) was taken in dry acetone (40 ml). It was refluxed for 12 hrs and the progress of reaction checked by TLC. Reaction mixture was filtered and the filtrate was concentrated to get oily compound which was further crystallized by benzene hexane mixture to get N-(4 methoxyphenyl)-N-ethyl [3-(naphthalen-2-yloxy)propylamine, crystallized as yellow oil, (yield 0.64 gm, 94.6%).

後処理

  1. temperatureIt was refluxed for 12 hrs
  2. customthe progress of reaction
  3. customReaction mixture
  4. filtrationwas filtered
  5. concentrationthe filtrate was concentrated
  6. customto get oily compound which
  7. customwas further crystallized by benzene hexane mixture

出典と根拠

ORDレコード
ord-c7a8b54195494acfa10a4169a5ff2089
出典データセット
uspto-grants-2006_07
特許番号
US07081465B2

反応ノート

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