Butyl iodide → HCID 21021917、化合物

HRID 1794111

反応式

HRID 1794111 の反応式
[F:1][C:2]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][C:3]=1[CH2:4][OH:5].I[CH2:12][CH2:13][CH2:14][CH3:15].[C:16]([OH:23])(=[O:22])/[CH:17]=[CH:18]/[C:19]([OH:21])=[O:20].[CH2:24]([C@@H:26]1[CH2:31][NH:30][CH2:29][CH2:28][N:27]1[C:32](OCC1C=CC(OC(F)F)=CC=1)=[O:33])C>>[C:16]([OH:23])(=[O:22])/[CH:17]=[CH:18]/[C:19]([OH:21])=[O:20].[CH3:24][C@@H:26]1[CH2:31][NH:30][CH2:29][CH2:28][N:27]1[C:32]([O:5][CH2:4][C:3]1[CH:6]=[C:7]([O:10][CH2:12][CH2:13][CH2:14][CH3:15])[CH:8]=[CH:9][C:2]=1[F:1])=[O:33]

参加物

4

反応物 3

HCID 10962Butyl iodideHCID 21021913(R)-4-Difluoromethoxybenzyl 2-ethylpiperazine-1-carboxylate fumarateHCID 691416144-Fluoro-3-(hydroxymethyl)phenol

生成物 1

HCID 21021917HCID 21021917、化合物

実験手順

(R)-5-Butoxy-2-fluorobenzyl 2-methylpiperazine-1-carboxylate fumarate was prepared from 2-fluoro-5-hydroxybenzyl alcohol, 1-iodobutane and (R) 1-chlorocarbonyl-2-methyl-4-tert-butoxycarbonylpiperazine according to the methods described for Examples 54 and 96 to give the product as a white solid (18%); melting point 171.6–171.7° C.; NMR δH (400 MHz, DMSO-d6) 0.928(3H, t, J 7.0 Hz), 1.167(3H, d, J 7.0 Hz), 1.421(2H, m, J 7.5 Hz), 1.676(2H, m, J 7.5 Hz), 2.564(2H, bm), 2.787(2H, bs), 2.982(2H, bm), 3.717(1H, bdd), 3.931(2H, t, J 6.5 Hz), 4.122(1H, bm), 5.078(2H, q), 6.566(2H, s), 6.929(2H, m) and 7.123(1H, t, J 9.0 Hz).

出典と根拠

ORDレコード
ord-b98b8a77a1784e2e99faa5a3d39e5d41
出典データセット
uspto-grants-2006_04
特許番号
US07022707B2

関連ノート

読み込み中…