Bromomethylcyclopropane → 2-Chloro-4-cyclopropylmethoxy-6-fluoro-benzylalcohol

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9].[CH:12]1([CH2:15]Br)[CH2:14][CH2:13]1>>[Cl:1][C:2]1[CH:3]=[C:4]([O:11][CH2:15][CH:12]2[CH2:14][CH2:13]2)[CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9]

参加物

反応物 2

HCID 81503Bromomethylcyclopropane

HCID 222200093-Chloro-5-fluoro-4-(hydroxymethyl)phenol

生成物 1

HCID 222200582-Chloro-4-cyclopropylmethoxy-6-fluoro-benzylalcohol収率 77%

実験手順

This compound was prepared from 3-Chloro-5-fluoro-4-hydroxymethyl-phenol and cyclopropylmethylbromide according to the procedure described in Example 179 to give the product as a yellowish oil (305 mg, 77%); MS (EI): 230.1 (M)+.

出典と根拠

ORDレコード: ord-2b10bbcdbd6b4d1e862ff81dc0a6f436
出典データセット: uspto-grants-2006_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07022707B2

反応ノート

読み込み中…