Dimethylformamide → 4-(fluoromethyl)benzoyl Chloride
反応式
[F:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][CH:4]=1.CN(C)C=O.S(Cl)([Cl:19])=O>C1C=CC=CC=1>[F:1][CH2:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([Cl:19])=[O:8])=[CH:5][CH:4]=1参加物
5
反応条件
- 温度
- 40 °C
実験手順
4-(Fluoromethyl)benzoic acid (6.20 g) was dissolved in 30 ml of benzene, and 0.3 ml of N,N-dimethylformamide was added and then 4.4 ml of thionyl chloride was added dropwise. The mixture was stirred for 1 hour at 40° C. and then heated to reflux for another 1 hour. The solvent was distilled off under reduced pressure to provide 6.70 g of the objective compound as pale yellow oil.
後処理
- temperatureheated
- temperatureto reflux for another 1 hour
- distillationThe solvent was distilled off under reduced pressure
出典と根拠
- ORDレコード
- ord-c961426a0dbf402bbf692d9738addc22
- 出典データセット
- uspto-grants-2006_04
- 特許番号
- US07022723B2
反応ノート
読み込み中…