Trifluoroacetic acid → HCID 22222315、化合物

HRID 1794602ノート

反応式

HRID 1794602 の反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][N:11]([CH:21]([C:24]1[N:25]([CH2:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[C:26](=[O:37])[C:27]2[C:32]([C:33]([F:36])([F:35])[F:34])=[N:31][O:30][C:28]=2[N:29]=1)[CH2:22][CH3:23])[C:12](=[O:20])[C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][CH2:8][CH2:9][CH2:10][N:11]([CH:21]([C:24]1[N:25]([CH2:38][C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=2)[C:26](=[O:37])[C:27]2[C:32]([C:33]([F:36])([F:35])[F:34])=[N:31][O:30][C:28]=2[N:29]=1)[CH2:22][CH3:23])[C:12](=[O:20])[C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 21022367HCID 21022367、化合物

生成物 1

HCID 22222315HCID 22222315、化合物収率 96%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 12 (52 mg, 0.083 mmol) in CH2Cl2 (4.0 mL) stirred at room temperature was added TFA (1.0 mL). The reaction mixture was stirred at room temperature for 30 min. Solvent was removed in vacuo, the residue was purified by preparative HPLC to give 13 as a white solid (42 mg, 96%). MS (ESI): 528 (M+H)+.

後処理

  1. customSolvent was removed in vacuo
  2. customthe residue was purified by preparative HPLC

出典と根拠

ORDレコード
ord-84931abe17874348b94f250d7e1fd492
出典データセット
uspto-grants-2006_04
特許番号
US07022850B2

反応ノート

読み込み中…