Water → 2-[1,2,3]Thiadiazol-4-yl-benzylamine

HRID 1795255ノート

反応式

HRID 1795255 の反応式
[N:1]([CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[N:12]=[N:13][S:14][CH:15]=1)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O>O1CCCC1>[S:14]1[CH:15]=[C:11]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[CH2:4][NH2:1])[N:12]=[N:13]1

参加物

5

反応物 3

HCID 962WaterHCID 11776TriphenylphosphineHCID 218662814-(2-Azidomethyl-phenyl)-[1,2,3]thiadiazole

生成物 1

HCID 114012722-[1,2,3]Thiadiazol-4-yl-benzylamine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 4-(2-azidomethyl-phenyl)-[1,2,3]thiadiazole (1.0 g, 4.6 mmol), triphenylphosphine (1.4 g, 5.5 mmol) and water (0.12 ml, 6.9 mmol) in tetrahydrofuran (20 ml) was stirred at room temperature overnight. Solvent evaporation and flash chromatography (silica gel, chloroform-2-propanol, 95:5–92:8) gave 2-[1,2,3]thiadiazole-4-yl-benzylamine; 1H NMR (CDCl3, 300 MHz) δ 8.87 (s, 1H), 7.67 (d, 1H, J=8 Hz), 7.45 (m, 3H), 3.88 (s, 2H).

後処理

  1. customSolvent evaporation and flash chromatography (silica gel, chloroform-2-propanol, 95:5–92:8)

出典と根拠

ORDレコード
ord-bb9f5f1d7f014c2cbf5bcaebf1df7ce9
出典データセット
uspto-grants-2006_04
特許番号
US07026324B2

反応ノート

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