5-Fluororesorcinol → Umbelliferone

HRID 1795445

反応式

HRID 1795445 の反応式
F[C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[C:4]([OH:9])[CH:3]=1>S(=O)(=O)(O)O>[OH:9][C:4]1[CH:5]=[C:6]2[C:7]([CH:4]=[CH:5][C:6](=[O:8])[O:8]2)=[CH:2][CH:3]=1

参加物

3

反応物 1

HCID 126587785-Fluororesorcinol

生成物 1

HCID 5281426Umbelliferone収率 146.9%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

1-Fluoro-3,5-dihydroxybenzene (1.0 g, 7.8 mmol) and ethyl 2-benzyl acetoacetate (1.72 g, 7.8 mmol) are suspended in 20 mL of 70% sulfuric acid at room temperature. The reaction mixture is stirred for 24 hours and poured into ice water. The solid is filtered and washed with water. The yellowish crude product is re-crystallized from hot ethanol to afford the 7-hydroxy coumarin intermediate (929 mg, 42%).

後処理

  1. filtrationThe solid is filtered
  2. washwashed with water
  3. customThe yellowish crude product is re-crystallized from hot ethanol

出典と根拠

ORDレコード
ord-b37451d75d234d86ab5520d8c78ba42f
出典データセット
uspto-grants-2006_04
特許番号
US07026491B2

関連ノート

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