Pyridine → 1-(2-Methoxy-2-oxoethyl)pyridinium chloride
反応式
[Cl:1]CCC([O-])=O.[N:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[C:13]([O:16][CH2:17]C)(=[O:15])[CH3:14]>>[Cl-:1].[CH3:17][O:16][C:13]([CH2:14][N+:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:15]参加物
4
反応条件
- 温度
- 80 °C
実験手順
In a 250 mL round-bottom flask with a stir bar was charged 2-chloromethylacetate (17.5 mL, 0.2 mol), ethyl acetate (50 mL), and pyridine (16.2 mL, 0.2 mol). The overall homogeneous solution was heated with a condenser at 80° C. for 24 h and the resulting heterogeneous white suspension was cooled to room temperature and filtrated under reduced pressure. The off-white filtrate was recrystallized from small amount of ethanol to give the title compound (27.4 g, 73%) as a white solid. MS (ES+): 152 (M)+.
後処理
- temperaturethe resulting heterogeneous white suspension was cooled to room temperature
- filtrationfiltrated under reduced pressure
- customThe off-white filtrate was recrystallized from small amount of ethanol
出典と根拠
- ORDレコード
- ord-a9679273c5824c37a46557a53f507314
- 出典データセット
- uspto-grants-2006_04
- 特許番号
- US07026326B2
反応ノート
読み込み中…