Water → 8-(Difluoromethyl)quinoline-5-carboxylic acid

HRID 1795747ノート

反応式

HRID 1795747 の反応式
[F:1][CH:2]([F:17])[C:3]1[C:12]2[N:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:6]([C:13]([O:15]C)=[O:14])=[CH:5][CH:4]=1.[OH-].[Na+].O>C(O)C>[F:17][CH:2]([F:1])[C:3]1[C:12]2[N:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:6]([C:13]([OH:15])=[O:14])=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 22179174Methyl 8-difluoromethyl-5-quinolinecarboxylate

生成物 1

HCID 221791868-(Difluoromethyl)quinoline-5-carboxylic acid収率 112%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
25 °C

実験手順

0.5 g (2.0 mmol) of methyl 8-difluoromethyl-5-quinolinecarboxylate was dissolved in 5 ml of ethanol, 0.43 g (10.5 mmol) of sodium hydroxide and 1 ml of water were added, and the mixture was stirred at 25° C. for 20 hours. The solvents were subsequently removed, the residue was taken up in water, washed twice with methylene chloride and adjusted to pH 1 using 10 N hydrochloric acid, and the precipitate was filtered off with suction. Drying gave 0.5 g of 8-difluoromethyl-5-quinolinecarboxylic acid (colorless crystals);

後処理

  1. customThe solvents were subsequently removed
  2. washwashed twice with methylene chloride
  3. filtrationthe precipitate was filtered off with suction
  4. customDrying

出典と根拠

ORDレコード
ord-daca5a902b094c5cb160bdc9bd25377e
出典データセット
uspto-grants-2006_04
特許番号
US07030063B1

反応ノート

読み込み中…