1H-1,2,4-Triazole → 7-([1,2,4]Triazol-1-ylmethyl)imidazo[1,2-alpha]pyrimidine

HRID 1796101ノート

反応式

HRID 1796101 の反応式
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[H-].[Na+].Cl.Cl[CH2:10][C:11]1[CH:16]=[CH:15][N:14]2[CH:17]=[CH:18][N:19]=[C:13]2[N:12]=1.C(=O)([O-])[O-].[K+].[K+].[Na].N1C=CN=N1>CN(C)C=O>[N:1]1([CH2:10][C:11]2[CH:16]=[CH:15][N:14]3[CH:17]=[CH:18][N:19]=[C:13]3[N:12]=2)[CH:5]=[N:4][CH:3]=[N:2]1

参加物

7

反応物 5

HCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 24758Sodium hydrideHCID 695607647-Chloromethylimidazo[1,2-alpha]pyrimidine hydrochloride2 回HCID 178507080HCID 178507080、化合物

生成物 1

HCID 695603727-([1,2,4]Triazol-1-ylmethyl)imidazo[1,2-alpha]pyrimidine収率 69%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒3 回

実験手順

To a solution of 1H-[1,2,4]triazole (2.2 g, 31.9 mmol) in anhydrous N,N-dimethylformamide (20 ml) under a nitrogen atmosphere was added sodium hydride (1.18 g, 29.4 mmol, 60% dispersion in oil) with caution in a portionwise manner. This mixture was then stirred for 20 min at room temperature. To a separate solution of 7-chloromethylimidazo[1,2-α]pyrimidine hydrochloride (5.0 g, 24.5 mmol), also dissolved in N,N-dimethylformamide (50 ml) under nitrogen, was added potassium carbonate (6.76 g, 49.0 mmol) and the mixture stirred for 5 min at room temperature. To the 7-chloromethylimidazo[1,2-α]pyrimidine solution was added the triazole sodium salt as a solution in N,N-dimethylformamide and the mixture stirred at room temperature for 16 h. Solvent was removed under reduced pressure and the resulting residue purified by flash column chromatography on silica eluting with dichloromethene, methanol and aqueous ammonia solution (33%) in the ratios 90:5:0.5 respectively to give 7-([1,2,4]triazol-1-ylmethyl)imidazo[1,2-α]pyrimidine (3.38 g, 69%) as a tan solid: δH (360 Mz, d6-DMSO) 5.63 (2H, s), 6.90 (1H, d, J 7), 7.71 (1H, d, J 1.3), 7.91 (1H, d, J 1.4), 8.04 (1H, s), 8.73 (1H, s), 8.97 (1H, d, J 7); m/z (ES+) 201 (M++H).

後処理

  1. stirringthe mixture stirred for 5 min at room temperature
  2. stirringthe mixture stirred at room temperature for 16 h
  3. customSolvent was removed under reduced pressure
  4. customthe resulting residue purified by flash column chromatography on silica eluting with dichloromethene, methanol and aqueous ammonia solution (33%) in the ratios 90:5:0.5 respectively

出典と根拠

ORDレコード
ord-ebfe4b700d62415c871a6f49e7011064
出典データセット
uspto-grants-2006_04
特許番号
US07030128B2

反応ノート

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