Trifluoroacetic acid → 2-Amino-1-oxazolo[4,5-b]pyridin-2-yl-butan-1-ol TFA salt

HRID 1796139

反応式

HRID 1796139 の反応式
C(OC(=O)[NH:7][C@H:8]([CH:11]([OH:21])[C:12]1[O:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[CH:18][CH:19]=2)[CH2:9][CH3:10])(C)(C)C.[C:23]([OH:29])([C:25]([F:28])([F:27])[F:26])=[O:24]>C(Cl)Cl>[OH:29][C:23]([C:25]([F:28])([F:27])[F:26])=[O:24].[NH2:7][CH:8]([CH2:9][CH3:10])[CH:11]([C:12]1[O:13][C:14]2[C:15]([N:20]=1)=[N:16][CH:17]=[CH:18][CH:19]=2)[OH:21]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 21048468(S)-[1-(hydroxy-oxazolo[4,5-b]pyridin-2-yl-methyl)-propyl]-carbamic acid tert-butyl ester

生成物 1

HCID 865883392-Amino-1-oxazolo[4,5-b]pyridin-2-yl-butan-1-ol TFA salt

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(S)-[1-(Hydroxy-oxazolo[4,5-b]pyridin-2-yl-methyl)-propyl]-carbamic acid tert-butyl ester (311 mg, 1 mmol) and MeCl2 (5 ml) were mixed and TFA (1 ml) was added at room temperature. After stirring for 1 hour, the solvent and excess TFA were removed under vacuum to produce 355 mg of 2-Amino-1-oxazolo[4,5-b]pyridin-2-yl-butan-1-ol TFA salt.

後処理

  1. customthe solvent and excess TFA were removed under vacuum

出典と根拠

ORDレコード
ord-d901b6c8fd29471daa906a9c3c9733c2
出典データセット
uspto-grants-2006_04
特許番号
US07030116B2

関連ノート

読み込み中…