Acetic Anhydride → 1-[2-(Chloromethyl)-1h-benzimidazol-1-yl]ethanone

HRID 1796342

反応式

HRID 1796342 の反応式
[Cl:1][CH2:2][C:3]1[NH:7][C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[N:4]=1.[CH3:12][C:13](OC(C)=O)=[O:14]>CN(C1C=CN=CC=1)C>[C:13]([N:7]1[C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[N:4]=[C:3]1[CH2:2][Cl:1])(=[O:14])[CH3:12]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 785712-Chloromethylbenzimidazole

生成物 1

HCID 2674041-[2-(Chloromethyl)-1h-benzimidazol-1-yl]ethanone収率 57%

試薬・触媒・溶媒 1

HCID 142844-(Dimethylamino)pyridine触媒

実験手順

2-(Chloromethyl)-1H-benzimidazole (3.32 g, 0.02 mol) and DMAP (0.2 g) in Ac2O (50 ml) were refluxed for 8 h. The excess Ac2O was evaporated under vacuum and the residue was purified by column chromatography (silica, EtOAc:hexanes 2:1, first fraction) to obtain 2.37 g of product 7 (57%)

後処理

  1. customThe excess Ac2O was evaporated under vacuum
  2. customthe residue was purified by column chromatography (silica, EtOAc:hexanes 2:1, first fraction)

出典と根拠

ORDレコード
ord-96bd3d86a5bb4ad297ba9d20200d8e5a
出典データセット
uspto-grants-2006_04
特許番号
US07030150B2

関連ノート

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