HCID 69597656、化合物 → HCID 69597610、化合物

反応式

[CH3:1][NH:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([S:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20]CC3C=CC=CC=3C)=[CH:16][CH:15]=2)(=[O:13])=[O:12])[CH:7]([C:29]23[O:36][CH2:35][C:32]([CH3:37])([CH2:33][O:34]2)[CH2:31][O:30]3)[CH:6]1[CH3:38])=[O:4].[H][H]>[OH-].[OH-].[Pd+2].C(O)C>[CH3:1][NH:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([S:11]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)(=[O:13])=[O:12])[CH:7]([C:29]23[O:36][CH2:35][C:32]([CH3:37])([CH2:31][O:30]2)[CH2:33][O:34]3)[CH:6]1[CH3:38])=[O:4]

参加物

実験手順

To an ethanol (15 ml) solution of 4-[4-(2-methyl-benzyloxy)-benzenesulfonyl]-2-methyl-3-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-piperazine-1-carboxylic acid methylamide (1.9 g, 3.48 mmol) was added 10% palladium hydroxide on carbon (370 mg). The mixture was shaken under about 20 psi hydrogen gas for about 1.5 hours. The resulting mixture was filtered through Celite® and concentrated in vacuo to give 1.55 g of the title compound (compound of formula XLV).