HCID 68967246、化合物 → 2-Methyl-2-(piperazin-1-yl)propan-1-ol
反応式
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17]([CH3:21])([CH3:20])[CH2:18][OH:19])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CO.[Pd]>[CH3:21][C:17]([N:14]1[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]1)([CH3:20])[CH2:18][OH:19]参加物
4
実験手順
A mixture of 4-(2-hydroxy-1,1-dimethylethyl)piperazine-1-carboxylic acid benzyl ester (3.0 g, 10.3 mmol) in methanol (70 mL) and palladium on charcoal (0.5 g, 10%) was hydrogenated at room temperature at 40 p.s.i. overnight. The mixture was filtered through Celite and the filtrate evaporated under reduced pressure to give the title compound (1.55 g, 98%) as a white solid.
後処理
- customwas hydrogenated at room temperature at 40 p.s.i
- customovernight
- filtrationThe mixture was filtered through Celite
- customthe filtrate evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-4c28b4a24d074699b1e7d2b2142151ea
- 出典データセット
- uspto-grants-2006_04
- 特許番号
- US07034016B2
反応ノート
読み込み中…