2,2,2-Trifluoroethanesulfonyl chloride → HCID 22174503、化合物
反応式
[NH2:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[CH3:24])=[O:17])=[C:12]([Cl:25])[CH:11]=1.[F:26][C:27]([F:34])([F:33])[CH2:28][S:29](Cl)(=[O:31])=[O:30]>N1C=CC=CC=1>[Br:8][C:6]1[CH:5]=[CH:4][C:3]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[CH3:24])=[O:17])=[C:12]([Cl:25])[CH:11]=2)=[C:2]([NH:1][S:29]([CH2:28][C:27]([F:34])([F:33])[F:26])(=[O:31])=[O:30])[CH:7]=1参加物
4
実験手順
The reaction was conducted as described in the preparation of compound 179 using {4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl}(2-methylphenyl)methanone (0.15 g, 0.35 mmol)(disclosed in WO 01/05744) in pyridine (0.47 mL) and trifluoroethanesulfonyl chloride (0.059 mL, 0.53 mmol). The reaction time was 4 h. Work up as described in the preparation of compound 179 afforded the title compound as brown crystals.