1-Butanaminium, N,N,N-tributyl-, fluoride, hydrate → HCID 9833987、化合物

HRID 1797398ノート

反応式

HRID 1797398 の反応式
[OH2:1].[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([CH2:27][CH2:28][C@H:29]([OH:35])[C:30]([CH3:34])([CH3:33])[C:31]#[N:32])(C(C)(C)C)(C)C>O1CCCC1>[OH:1][CH2:27][CH2:28][C@H:29]([OH:35])[C:30]([CH3:34])([CH3:33])[C:31]#[N:32]

参加物

4

反応物 2

HCID 162116731-Butanaminium, N,N,N-tributyl-, fluoride, hydrateHCID 235679315-tert-butyldimethylsilyl-2,2-dimethyl-3(S)hydroxy-pentane-nitrile2 回

生成物 1

HCID 9833987HCID 9833987、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

12.18 g (46.61 mmol) of tetrabutylammonium fluoride hydrate is added to a solution that consists of 3 g (11.65 mmol) of 5-tert-butyldimethylsilyl-2,2-dimethyl-3(S)hydroxy-pentane-nitrile of the title compound of Example 8b, dissolved in 40 ml of tetrahydrofuran, and it is stirred for 16 hours at room temperature. Then, it is evaporated to the dry state in a vacuum. The residue is purified by RP-18 chromatography (mobile solvent: acetonitrile/water gradient).

後処理

  1. customThen, it is evaporated to the dry state in a vacuum
  2. customThe residue is purified by RP-18 chromatography (mobile solvent: acetonitrile/water gradient)

出典と根拠

ORDレコード
ord-2c798bcd99a549069115dc8688a4a024
出典データセット
uspto-grants-2006_04
特許番号
US07034165B2

反応ノート

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