Trifluoroacetic acid → 2-[(3-Hydroxypyridin-2-yl)formamido]acetic acid
反応式
C([O:5][C:6](=[O:18])[CH2:7][NH:8][C:9]([C:11]1[C:16]([OH:17])=[CH:15][CH:14]=[CH:13][N:12]=1)=[O:10])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[OH:17][C:16]1[C:11]([C:9]([NH:8][CH2:7][C:6]([OH:18])=[O:5])=[O:10])=[N:12][CH:13]=[CH:14][CH:15]=1参加物
4
実験手順
To a solution of [(3-hydroxy-pyridine-2-carbonyl)-amino]-acetic acid tert-butyl ester, 29, (0.070 g, 0.277 mmol) in CH2Cl2 (4 mL) is added TFA (1 mL). The resulting solution is stirred for 5 hours then concentrated under reduced pressure to afford 0.054 g (99% yield) of the desired compound as a colorless solid. 1H NMR (400 MHz, MeOD) δ ppm 8.09 (1 H, d, J=3.3 Hz), 7.36-7.59 (2 H, m), 4.08 (2 H, s). HPLC-MS: m/z 197 [M+H]+.
後処理
- concentrationthen concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-71735b5095e643d59cd8034892c96aae
- 出典データセット
- uspto-grants-2013_01
- 特許番号
- US08343952B2
反応ノート
読み込み中…