Hydrochloric Acid → 2,4-Dihydroxy-6-methoxymethyl-benzaldehyde

HRID 1798059ノート

反応式

HRID 1798059 の反応式
COC[O:4][C:5]1[CH:12]=[C:11]([O:13]COC)[CH:10]=[C:9]([CH2:17][O:18][CH3:19])[C:6]=1[CH:7]=[O:8].Cl>C1COCC1.CCOC(C)=O>[OH:4][C:5]1[CH:12]=[C:11]([OH:13])[CH:10]=[C:9]([CH2:17][O:18][CH3:19])[C:6]=1[CH:7]=[O:8]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 582925712,4-Bis-methoxymethoxy-6-methoxymethyl-benzaldehyde

生成物 1

HCID 582926702,4-Dihydroxy-6-methoxymethyl-benzaldehyde収率 100%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2,4-bis-methoxymethoxy-6-methoxymethyl-benzaldehyde (3.93 g, 14.45 mmol) in THF (30 mL) was added 6 N HCl (10 mL). The mixture was stirred at room temperature for 20 hours then diluted with EtOAc (200 mL). The mixture was washed with brine, dried and concentrated to give 2,4-dihydroxy-6-methoxymethyl-benzaldehyde (2.62 g, 100%). 1H NMR (400 MHz, CDCl3δ 12.40 (s, 1H), 10.10 (s, 1H), 6.41 (s, 1H), 6.30 (s, 1H), 5.60 (s, 1H), 4.61 (s, 2H), 3.40 (s, 3H).

後処理

  1. washThe mixture was washed with brine
  2. customdried
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-38a82620bfd6499eaee3241cfee20708
出典データセット
uspto-grants-2013_01
特許番号
US08343944B2

反応ノート

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