1-Butanol → (2-Butoxy-2-oxoethyl)azanium chloride

HRID 17985

反応式

HRID 17985 の反応式
Cl.[NH2:2][CH2:3][C:4]([OH:6])=[O:5].S(Cl)([Cl:9])=O.[CH2:11](O)[CH2:12][CH2:13][CH3:14]>>[Cl-:9].[CH2:11]([O:5][C:4](=[O:6])[CH2:3][NH3+:2])[CH2:12][CH2:13][CH3:14]

参加物

4

反応物 3

HCID 2631-ButanolHCID 22316Glycine HydrochlorideHCID 24386Thionyl Chloride

生成物 1

HCID 133112781(2-Butoxy-2-oxoethyl)azanium chloride

反応条件

温度
70 °C

実験手順

To a suspension of glycine hydrochloride (400 g, 3.58 mol) in n-butanol (8 L), thionyl chloride (1.37 L, 18.84 mol) was added slowly dropwise. After addition was complete, the reaction was heated at 70° C. overnight. The product mixture was concentrated under vacuum and the residue was triturated with a mixture of heptane/ethyl acetate. The white solid precipitated was filtered and dried under a stream of dry nitrogen to provide the title compound.

後処理

  1. additionwas added slowly dropwise
  2. additionAfter addition
  3. concentrationThe product mixture was concentrated under vacuum
  4. customthe residue was triturated with a mixture of heptane/ethyl acetate
  5. customThe white solid precipitated
  6. filtrationwas filtered
  7. customdried under a stream of dry nitrogen

出典と根拠

ORDレコード
ord-a4fd72100998485abe94e958322a2d24
出典データセット
uspto-grants-2010_06
特許番号
US07741315B2

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