3,4,5-Trimethyl-piperazine-1-carboxylic acid benzyl ester → 1,2,6-Trimethylpiperazine

HRID 1798551ノート

反応式

HRID 1798551 の反応式
C(OC([N:11]1[CH2:16][CH:15]([CH3:17])[N:14]([CH3:18])[CH:13]([CH3:19])[CH2:12]1)=O)C1C=CC=CC=1>CCO.[Pd]>[CH3:18][N:14]1[CH:15]([CH3:17])[CH2:16][NH:11][CH2:12][CH:13]1[CH3:19]

参加物

4

反応物 1

HCID 687346163,4,5-Trimethyl-piperazine-1-carboxylic acid benzyl ester

生成物 1

HCID 219737471,2,6-Trimethylpiperazine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

Under an inert atmosphere of nitrogen, 3,4,5-trimethyl-piperazine-1-carboxylic acid benzyl ester (1 eq, 1.87 mmol, 0.49 g) is dissolved in EtOH (20 ml) and palladium on carbon (0.1 eq, 0.187 mmol, 0.2 g) is added. The reaction is stirred at room temperature under an atmosphere of hydrogen for 4 hrs. The reaction mixture is filtered through Celite® and the solvent evaporated under vacuo to afford the title compound.

後処理

  1. filtrationThe reaction mixture is filtered through Celite®
  2. customthe solvent evaporated under vacuo

出典と根拠

ORDレコード
ord-3078ad1b2ace4a1baf621956ef064d5c
出典データセット
uspto-grants-2013_01
特許番号
US08343966B2

反応ノート

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